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Theobromine, formerly known as xanthate, is a bitter alkaloid of a cocoa plant with a chemical formula of C7H8N4O2. It is found in chocolate and in many other foods, including the leaves of tea and the nuts of Cora (or cola). It is classified as a xanthine alkaloid, which also includes similar theophylline and caffeine. The difference is that the caffeine has an additional methyl group (see pharmacological section).
Despite its name, the compound does not contain bromine-theobromine derived from the cocoa tree, the name of the cocoa tree (which itself consists of the Greek roots ("god") and bromine ("food"), meaning to give alkaloids and other bases A nitrogen-containing suffix of "God's food".
Theobromine is a slight water-soluble (330 mg / L), crystalline bitter powder. Theobromine is white or colorless, but commercial samples may turn yellow. It has a similar but not as caffeine in the human nervous system, making it a smaller homologue. Theobromine is the isomer of theophylline, as well as the shrimp. Theobromine is classified as dimethylxanthine.
Theobromine is the first time that Russian chemist Alexander Voskresensky discovered cocoa beans in 1841. Hermann Emil Fischer (Hermann Emil Fischer) in 1882 for the first time reported xanthine in the synthesis of theobromine.
Theobromine is a vasodilator (vasodilator), a diuretic (urinary aid) and a cardiac stimulant. It is not currently used as a medicinal drug.
Theobromine increases urine production. Because of this diuretic effect and its ability to dilate blood vessels, theobromine has been used to treat high blood pressure. American Journal of Clinical Nutrition pointed out that in future studies should consider the historic use of theobromine as a treatment for other circulatory problems, including arteriosclerosis, certain vascular diseases, angina and hypertension.
After the discovery of the late 19th century, theobromine was put into use in 1916, when the "Principles of Treatment" were published as edema treatments (part of the body excess liquid), syphilis angina pectoris and degenerative angina.
In the human body, the level of theobromine in the consumption of 6-10 hours after halving
Theobromine is also used in birth defects involving mice and rabbits. In the forced feeding of the rabbit after the attention of the fetal weight loss, but in the other after the addition of theobromine did not see. Birth defects are not seen in rats. Cocoa class in the future can prevent the application of cancer has been patented.
Theobromine has also been shown to improve the micro hardness of enamel, which may increase the potential for anti-tooth decay.
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