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L-thyroxine, also known as L-thyroxine, is a form of production of thyroid hormone thyroid hormone (T4). It is used to treat thyroid hormone deficiency, including severe forms called viscous coma coma. It can also be used to treat and prevent certain types of thyroid tumors. It does not mean to lose weight. The maximum effect from a given dose may take up to six weeks.
Excess doses of side effects include weight loss, heat resistance, sweating, anxiety, difficulty with sleep, tremor and fast heart rate. It is not recommended for people who have recently developed a heart attack. The use during pregnancy is found to be safe. The recommended dose is based on routine measurements of TSH and T4 levels in the blood. Most of the role of L-thyroxine is converted to triiodothyronine (T3).
L-thyroxine was first manufactured in 1927. It is the list of essential medicines in the World Health Organization, the most effective and safe drug for health systems.  L-thyroxine can be used as a generic drug. The wholesale cost of developing countries is about $ 0.58 to $ 12.28 per month. In the United States, a typical treatment month is less than $ 25.
Levothyroxine is typically used to treat hypothyroidism, and is the treatment of choice for people with hypothyroidism, who often require lifelong thyroid hormone therapy. It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing. Levothyroxine is also used as interventional therapy in people with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion. A subset of people with hypothyroidism treated with an appropriate dose of levothyroxine will describe continuing symptoms despite TSH levels in the normal range. In these people, further laboratory and clinical evaluation is warranted as they may have another cause for their symptoms. Furthermore, it is important to review their medications and possible dietary supplements as several medications can affect thyroid hormone levels.
Levothyroxine is also used to treat subclinical hypothyroidism which is defined by an elevated TSH level and a normal-range free T4 level without symptoms. Such people may be asymptomatic and whether they should be treated is controversial. One benefit of treating this population with levothyroxine therapy is preventing development of hypothyroidism. As such, it is recommended that treatment should be taken into account for patients with initial TSH levels > 10 mIU/L, people with elevated thyroid peroxidase antibody titers, people with symptoms of hypothyroidism and TSH levels between 5– 10 mIU/L, and women who are pregnant or want to become pregnant. Oral dosing for patients with subclinical hypothyroidism is 1 µg/kg/day.
It is also used to treat myxedema coma, which is a severe form of hypothyroidism characterized by mental status changes and hypothermia. As it is a medical emergency with a high mortality rate, it should be treated in the intensive care unit with thyroid hormone replacement and aggressive management of individual organ system complications.
Generic levothyroxine, 25 µg oral tablet
Dosages vary according to the age groups and the individual condition of the person, body weight and compliance to the medication and diet. Other predictors of the required dosage are sex, BMI, deiodinase activity (SPINA-GD) and etiology of hypothyroidism. Annual or semiannual clinical evaluations and TSH monitoring are appropriate after dosing has been established. Levothyroxine is taken on an empty stomach approximately half an hour to an hour before meals. As such, thyroid replacement therapy is usually taken 30 minutes prior to eating in the morning. For patients with trouble taking levothyroxine in the morning, bedtime dosing is effective as well. A recent study published in JAMA showed greater efficacy of levothyroxine when taken at bedtime.
Poor compliance in taking the medicine is the most common cause of elevated TSH levels in people receiving appropriate doses of levothyroxine.
According to the provisions of the doctor, taking levothyroxine. Follow all directions in your prescription label. Your doctor occasionally changes your dose. Do not use the drug in a larger or smaller amount or longer than the recommended drug.
If you take it on an empty stomach, use L-thyroxine at least 30 minutes before breakfast. Follow the doctor's dose instructions and take the medication at the same time every day.
Bottle or capsules with whole glass (8 ounces) of water. The tablet may dissolve quickly and may expand in your throat.
If a child is using the drug, please tell your doctor whether the child has a weight change. Dose is based on the weight of the child, and any change may affect your child's dose.
It may take several weeks for your body to start reacting to levothyroxine. Even if you feel good, continue to use this drug. You may need to use thyroid drugs for the rest of your life.
When using left thyroxine, you may need frequent medical examinations. Tell any doctor or dentist who treats you and you are using this medicine.
Store at room temperature to avoid moisture and heat
Do not share this drug with another person, even if they have the same symptoms.
Adverse events are usually caused by improper administration. Long-term inhibition of TSH values below normal values can cause frequent cardiac side effects and contribute to a reduction in bone mineral density (low TSH levels are also known to contribute to osteoporosis).
Too high doses of L-thyroxine produce the effect of simulating hyperthyroidism. Excessive can lead to palpitations, abdominal pain, nausea, anxiety, confusion, excitement, insomnia, weight loss, increased appetite. Allergic reactions to drugs are characterized by difficulty breathing, shortness of breath, or swelling of the face and tongue. Acute overdose may cause fever, hypoglycemia, heart failure, coma, and unrecognized adrenal insufficiency.
Acute large doses may be life-threatening; treatment should have symptoms and support. A large amount of excess is associated with increased sympathetic activity, and therefore requires beta-blockers for treatment.
6 hours to 11 days after ingestion, excessive effect.
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