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Rimonabant (also known as SR141716; trade name Acomplia, Zimulti) is an anorexia anti-obese drug that was first approved in Europe in 2006 but was withdrawn globally in 2008 due to serious psychiatric side effects. It has never been approved in the United States. Rimonabant is the inverse agonist of cannabinoid receptor CB1 and is the first drug approved in this class.
Acomplia (Limone) is the first of a new class of therapeutic drugs called cannabinoid-1 receptor blockers (CB1).
Acomplia is studied for the treatment of obesity and related disorders.
Acomplia is being used to supplement diets and exercise to treat obese or overweight patients with type 2 diabetes and abnormal levels of blood in the blood.
Sanofi believes that Acomplia can also prevent the risk of cardiovascular disease.
Waist large (male 102 cm, female 88 cm) patients are said to take the most drugs.
Clinical trial data submitted to regulators showed that Limonaben caused up to 10% of subjects with suicidal thoughts about 1% of depressive disorder or mood changes, whereas in Europe, contraindications were those with mental disorders, including depression or Suicide.
In addition, nausea and upper respiratory tract infections are common (more than 10% of people occur) adverse reactions; common adverse events (occurring between 1% and 10%) include gastroenteritis, anxiety, irritability, insomnia and other sleep Obstruction, hot flushes, diarrhea, vomiting, dry or itching of the skin, tendonitis, muscle spasms and spasms, fatigue, cold similar symptoms, and an increased risk of decline.
The FDA's advisory committee raised concerns that, depending on the animal data, it appears that the treatment window for CNS toxicity and specific seizures is almost non-existent; the therapeutic dose and dose that cause the onset of the animal appear to be the same.
When the EMA reviewed the monitoring data after listing, it was found that the risk of mental disorders using people in Limone was doubled.
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