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Methyl hexamine (trade name Forthane, Geranamine) or methyl hexamine, commonly known as 1, 3-dimethylamine (1,3-DMAA) or simple dimethylamine (DMAA) Invented and developed indirect sympathetic drugs, as inhaled nasal decongestants in 1944 was voluntarily withdrawn from the market.
Since 2006, methylhexylamine has been widely marketed as a stimulant or fortified dietary supplement, which claims to be similar to some of the compounds found in geraniums, but it has been questioned as some adverse events, at least Five deaths have been associated with a supplement containing methylhexylamine. It is banned by many sports authorities and government agencies.
The LD50 of intravenous methylhexylamine was 39 mg / kg in mice and 72.5 mg / kg in rats
The US Food and Drug Administration has said it is known that methylhexylamine can shrink blood vessels and arteries, which can increase blood pressure and may lead to cardiovascular events, from shortness of breath and tightening the chest to heart attack. "Many adverse events have been reported to have at least five deaths associated with methylated hexamine-containing dietary supplements.
A review by a group convened by the US Department of Defense whether to study whether the military should banned methylhexylamine supplements at its base store concluded: "The available evidence does not ultimately determine the DMAA-containing substances with adverse medical causes However, the consistent subject of the study is that DMAA uses potentially affect cardiovascular function, just like other sympathomimetic stimulants, without further rigorous research designed to assess the safety of DMAA, especially in patients with other substances The use of DMAA-containing products to increase the likelihood of serious adverse events, even with the use of DMAA-related products, and the use of DMAA-related products, The overall risk of DMAA-related events is low, and resu has a corresponding impact on certain service members and other beneficiaries. The DMAA should be further studied to assess its safety. The data from case-control studies show that the frequency and number of DMAA use and specific The risk of AMEs, especially thermal damage and rhabdomyolysis, requires more detail The safety review team recommends that ... continue to prohibit the sale of DMAA-containing products on exchanges and concessions. The Panel considers that the evidence supports the use of DMAA-containing products for the service of another death or catastrophic disease with sufficient risk, without any offset the benefits of these products.
The DMAA regulatory review in 2012 found that "1,3-dimethylamine (DMAA) is a common pressurized amine that is commonly used in food additives at 25-65 mg doses, and historically the compound has been used for nasal reduction However, we reviewed the literature on DMAA and similar amines to infer valid oral doses, according to the fact that the oral administration of the suppository was not confirmed by oral administration, Our findings, we conclude that 4 mg of DMAA should be considered as a bronchodilator effective for each dose unit, and food supplements exceeding this limit are in fact subject to the Pharmaceutical Code and require permission to be expected to be higher than 100- A dose of 200 mg will cause serious adverse events.
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