Megestrol Acetate Powder Female Hormone Steroid Contraceptive CAS595-33-5
Chemical Properties:Crystalline Solid
Usage:Progestogen;Progesterone receptor agonist,Orally active progestogen; formerly used in combinations as oral contraceptive,treatment of endometrial hyperplasia
Megestrol acetate Description
Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.
Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.
Megestrol acetate COA
White to creamy white crystalline powder
White crystalline powder
Completeness of solution
Meets the requirements.500mg being
dissolved in 10ml of acetone
Insoluble in water, sparingly soluble in
alcohol. Slightly soluble in ether and in
fixed oils, soluble in acetone; very soluble
Specific optical rotation
Megestrol acetate Application
Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.
Megestrol acetate Dosage
In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.
Dosage: Megestrol acetate is available as 5 mg, 20 mg and 40 mg tablets and in oral suspensions of 125 mg/ml and 40 mg/ml. It is used at a dose of 5 mg in combination with an estrogen for contraception. Appetite stimulation is achieved with doses ranging from 400 mg to 800 mg a day. Doses used to treat cancer usually range from 40 mg to 320 mg.
White crystalline powder
Loss on drying
Conform to standard
Identical with and at least nearly equivalent to the pregnenolone reference standard with reference to integrity, intensity, spot color and RF value, compared to sample FR0025
Related substances (HPLC)
|Any single impurity: ≤0.4 a/a%|
|Total impurities: ≤1.0 a/a%|
Assay (dried basis)
The test result of the above mentioned product meets the enterprise standard
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