Megestrol Acetate Powder Female Hormone Steroid Contraceptive CAS595-33-5

Megestrol Acetate Powder Female Hormone Steroid Contraceptive CAS595-33-5

Megestrol Acetate Powder Female Hormone Steroid Contraceptive CAS595-33-5 Whatsapp:+8618126147481 Skype:cherrysendi Emial:cherrysendi@chembj.com Megestrol acetate CAS:595-33-5 MF:C24H32O4 MW:384.51 EINECS:209-864-5 Chemical Properties:Crystalline Solid Usage:Progestogen;Progesterone receptor...

Product Details

Megestrol Acetate Powder Female Hormone Steroid Contraceptive CAS595-33-5

Whatsapp:+8618126147481

Skype:cherrysendi

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Megestrol acetate

CAS:595-33-5

MF:C24H32O4

MW:384.51

EINECS:209-864-5

Chemical Properties:Crystalline Solid

Usage:Progestogen;Progesterone receptor agonist,Orally active progestogen; formerly used in combinations as oral contraceptive,treatment of endometrial hyperplasia


Megestrol acetate Description

Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.

Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.


Megestrol acetate COA

Test Items

Specification

Test Results

Appearance

White to creamy white crystalline powder

White crystalline powder

Identification

IR

Complies

Completeness of solution

Meets the requirements.500mg being

Complies

dissolved in 10ml of acetone


Solubility

Insoluble in water, sparingly soluble in

Complies

alcohol. Slightly soluble in ether and in


fixed oils, soluble in acetone; very soluble


in chloroform.


Melting range

213ºC~220ºC

217ºC

Specific optical rotation

+8.8°~ +12.0°

+11.6°

Water

≤0.5%

0.1%

Residue roration

≤0.2%

0.06

Heavy metals

≤0.002%

Complies

Assay

97.0%~103.0%

99.6%

Residual solvents

Methanol≤1000ppm

74ppm

Ethanol≤1000ppm

39ppm

Methylene chloride≤500ppm

28ppm

Tetrahydrofuran≤300ppm

ND

Benzene≤2ppm

ND


Megestrol acetate Application
Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.


Megestrol acetate Dosage

In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.
Dosage: Megestrol acetate is available as 5 mg, 20 mg and 40 mg tablets and in oral suspensions of 125 mg/ml and 40 mg/ml. It is used at a dose of 5 mg in combination with an estrogen for contraception. Appetite stimulation is achieved with doses ranging from 400 mg to 800 mg a day. Doses used to treat cancer usually range from 40 mg to 320 mg.


Pregnenolone Specifications

Test

Result

Specification

Appearance

Qualified

White crystalline powder

Melting point

182~190.5℃

180~193℃

Loss on drying

0.22%

0.50%max

Specific rotation

+28°

+27°~+30°

Identification(TLC)

Conform to standard

Identical with and at least nearly equivalent to the pregnenolone reference standard with reference to integrity, intensity, spot color and RF value, compared to sample FR0025

Related substances (HPLC)

Any single
impurities: 0.30a/a%

Δ14-pregnenolone: ≤0.3a/a%

17-Alpha: ≤0.3a/a%
5α/β-pregnenolone≤0.4 a/a%
Any single impurity: ≤0.4 a/a%

0.64%

Total impurities: ≤1.0 a/a%

Assay (dried basis)

99.36%

99.0%min

Conclusion

The test result of the above mentioned product meets the enterprise standard


Famale Hormone Steroids we offer

Famale Hormone

CAS

Anti Estrongen Steriods

CAS

Estriol

50-27-1

Anastrozole

120511-73-1

Pregnenolone

145-13-1

Clomifene Citrate

50-41-9

Altrenogest

850-52-2

Toremifene citrate

89778-27-8

Megestrol acetate

595-33-5

Tamoxifen citrate

54965-24-1

Medroxyprogesterone acetate

71-58-9

Tamoxifen

10540-29-1

Estrone

53-16-7

Letrozole

112809-51-5

Mifepristone

84371-65-3

Methoxydienone

2322-77-2

Ethinylestradiol

57-63-6

Trilostane

13647-35-3

Drospirenone

67392-87-4



Estradiol valerate

979-32-8



Estradiol benzoate

50-50-0




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