Female Hormone Drospirenone Arbolactone Powder CAS67392-87-4 Estrogen Steroids

Female Hormone Drospirenone Arbolactone Powder CAS67392-87-4 Estrogen Steroids

Female Hormone Drospirenone Arbolactone Powder CAS67392-87-4 Estrogen Steroids Whatsapp:+8618126147481 Skype:cherrysendi Emial:cherrysendi@chembj.com Drospirenone Product Name: Drospirenone Synonyms: arbolactone CAS: 67392-87-4 MF: C24H30O3 MW: 366.49 EINECS: 266-679-2 Mp: 196-200C Alpha:...

Product Details

Female Hormone Drospirenone Arbolactone Powder CAS67392-87-4 Estrogen Steroids

Whatsapp:+8618126147481

Skype:cherrysendi

Emial:cherrysendi@chembj.com


Drospirenone

Product Name: Drospirenone
Synonyms: arbolactone
CAS: 67392-87-4
MF: C24H30O3
MW: 366.49
EINECS: 266-679-2
Mp: 196-200C
Alpha: -180(c=0.5, chloroform)
Storage temp: -20C Freezer
Appearance: Off-White Crystalline Powder


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What is Drospirenone

Drospirenone (INN, USAN), also known as 1,2-dihydrospirorenone, is a synthetic hormone used in birth control pills and postmenopausal hormone replacement therapy pills.

It is sold under the brand names Yasmin, Yasminelle, Yaz, Beyaz, Ocella, Zarah, Daylette and Angeliq, all of which arecombination products of drospirenone with an estrogen such as ethinylestradiol or estradiol.


Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has potent antimineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and has also been shown to possess mild antiandrogen activity.
The antimineralocorticoid properties exhibited by drospirenone promote sodium excretion and prevent water retention.


Drospirenone COA

Description

White or almost white power

Almost white power

Identification

Specific rotation
IR

Conforms
Conforms

Specific rotation

-187.0°~ -193.0°

-192.3°

Loss on drying

≤0.5%

0.23%

Related Substances

Unspecified impurity <0.10%
Total impurities ≤0.3%

0.09%
0.27%

Assay(Dry Basis)

98.0%~102.0%

99.0%

Conclusion

Passed


Drospirenone Application
Drospirenone is an ingredient in some birth control pills and hormone replacement therapy. In combination with ethinyl estradiolit is used as contraception, and for women who want contraception it is also approved by the U.S. Food and Drug Administration(FDA) to treat moderate acne and premenstrual dysphoric disorder.


Drospirenone is an aldosterone antagonist with potassium-sparing properties, though in most cases no increase of potassium levels is to be expected. In women with mild or moderate renal insufficiency, or in combination with chronic daily use of other potassium-sparing medications (ACE inhibitors, angiotensin II receptor antagonists, potassium-sparing diuretics, heparin, aldosterone antagonists, or NSAIDs), a potassium level should be checked after two weeks of use to test for hyperkalemia. In addition to contraindications common to all combined estrogen-progestin medications, drospirenone-containing medications are contraindicated in women with severe renal insufficiency according to European Medicines Agency (EMA)-approved labels, and contraindicated in women with renal insufficiency, adrenal insufficiency, or liver disease according to FDA-approved labels.


Drospirenone usage

Drospirenone and ethinyl estradiol combination is used to prevent pregnancy. It is a birth control pill that contains two types of hormones, ethinyl estradiol and drospirenone, and when taken properly, prevents pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.


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