Famale Hormone steroids Estriol Powder Pharmaceutical Raw CAS50-27-1
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation.
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3.Shipping Ways:EMS,HKEMS,TNT,DHL,FedEX,UPS etc.
4.Air transport for large quantity
5.Shipping time:Most countries can arrived within 3-10 days door to door
Estriol can be measured in maternal blood or urine and can be used as a marker of fetal health and wellbeing.is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta.
If levels of unconjugated estriol (uE3 or free estriol) are abnormally low in a pregnant woman, this may indicate chromosomal or congenital anomalies like Down syndrome or Edward's syndrome. It is included as part of the triple test & quadruple test for antenatal screening for fetal anomalies.
Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal-placental health than non-stress testing. Conditions which can create false positives and false negatives in estriol testing for fetal distress include preeclampsia, anemia, and impaired kidney function.
Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.
Estriol may play a role in the development of breast cancer, but based on in vitro research, does appea to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada.
White or almost white crystalline powder
White crystalline powder
Completeness of solution
Clear and free from undissolved solid
(1) complies by IR
Residue on Ignition
Not more than 0.1%
Loss on drying
Not more than 0.5
Total impurities not more than 2.0%
It should contain 97.0% to 102.0% of C18H24O3 calculated on dried basis
It should be 90% below 30m
Conforms to USP36
Studies suggest that when the lower-potency estrogen, estriol, is administered topically, it does not increase the risk of hormone-dependent cancers of the breast or endometrium (uterine lining).1-3 However, having weaker estrogenic effects does not mean that estriol has none of the benefits that come with more potent estrogens. Studies suggest that estriol reduces symptoms of menopause, such as hot flashes and vaginal dryness, but with a better safety profile compared with more potent estrogens.1,4,5 This makes estriol a better choice for bioidentical hormone-replacement treatment regimes.
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