Estrogen Hormones Misoprostol Mifepristone Steroid Powder CAS 84371-65-3

Estrogen Hormones Misoprostol Mifepristone Steroid Powder CAS 84371-65-3

Estrogen Hormones Misoprostol Mifepristone Steroid Powder CAS 84371-65-3 Whatsapp:+8618126147481 Skype:cherrysendi Emial:cherrysendi@chembj.com Mifepristone CAS: 84371-65-3 MF: C29H35NO2 MW: 429.59 Chemical Properties Pale Yellow Solid Usage A progesterone receptor antagonist with partial...

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Estrogen Hormones Misoprostol Mifepristone Steroid Powder CAS 84371-65-3

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Mifepristone

CAS: 84371-65-3
MF: C29H35NO2
MW: 429.59
Chemical Properties Pale Yellow Solid
Usage A progesterone receptor antagonist with partial agonist activity. Abortifacient.
Usage glutamate uptake inhibitor, AMPA blocker
Biological Activity Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo . Is a silent antagonist at PR and has a higher affinity than progesterone.


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Mifepristone Description

Mifepristone antagonizes cortisol action competitively at the receptor level.
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's syndrome (due to ectopic/neoplastic ACTH/cortisol secretion). During early trials, it was known as RU-38486 or simply RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed-often amid controversy.


Mifepristone application
Mifepristone is used alone or in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 49 days or less since your last menstrual period began. Mifepristone is in a class of medications called antiprogestational steroids. It works by blocking the activity of progesterone, a substance your body makes to help continue pregnancy.

Mifepristone is also available as another product (Korlym), which is used to control hyperglycemia (high blood sugar) in people with a certain type of Cushing's Syndrome in which the body makes too much of the hormone cortisol. This monograph only gives information about mifepristone (Mifeprex), which is used alone or in combination with another medication to end an early pregnancy. If you are using mifepristone to control hyperglycemia caused by Cushing's syndrome, read the monograph entitled mifepristone (Korlym) that has been written about this product.


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Mifepristone COA

Test

Analysis Standard

Results

Description

Light Yellowish Crystalline Powder

Light Yellowish Crystalline Powder

Identification

304nm,260nm.

confirmed

Melting Point

192°C~196°C

192°C~196°C

Specific Rotation

+124°~ +129°

+127.1°

(HPLC)
Related substances

(1)(Single):≤0.5%

0.31%

(2)(Total):≤1.0%

0.59%

Loss On Drying

≤0.5%

0.1%

Assay

≥98.5%

99.5%

Sieve analysis

≤30μm

confirmed

Conclusion

This product conforms to USP31


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