Estradiol Benzoate EB Powder Pharmaceutical Raw Materials Antiacne Antineoplastic CAS 50-50-0
Product name: Estradiol benzoateCAS
No.: 50-50-0M.F.: C25H28O3M.W.: 376.49
Quality standards: EP5.0
Appearance: Almost white crystalline powder or colourless crystals
What is Estradiol benzoate
Estradiol benzoate (INN; brand names Agofollin, Diffolisterol,Progynon-B, many others), or oestradiol benzoate (BAN), is a syntheticester, specifically the 3-benzoyl ester, of the natural estrogen,estradiol. It was the first form of estrogen to be marketed, patented by Schering-Kahlbaun in 1936 in an oil preparation for injectable use and introduced later that year as Progynon-B. Though it is still in widespread use today, it has been mostly superseded by newer forms of estradiol with improved pharmacokinetics in which require less frequent administration such as estradiol cypionate and estradiol valerate.
Estradiol benzoate benefits
Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to induce estrus in domestic livestock. This compound binds to the human and murine estrogen receptor, and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction in binding affinity compared to estradiol.
Estradiol benzoate COA
White crystalline powder
97 .0~ 103.0%
Loss on drying
total impurities ≤1.0%
any individual impurity ≤0.5%
Estradiol benzoate effects
The effects of daily injections of 5 microgram estradiol benzoate (EB) on the patterns of food and ethanol consumption were studied in ovarectomized rats given free access to food, a 10% ethanol solution, and water. EB led to an immediate, but transient, suppression of both food and ethanol intake. The time course and magnitude of these effects were virtually identical. While the decrease in total food intake was achieved by a permanent decrease in the duration of eating bouts, the decline in total ethanol consumption apparently resulted from decreased rates of licking within bouts. Gradual increases in the frequency of eating and ethanol-drinking bouts allowed total food and ethanol intake to return to baseline within three weeks of the first injection. Total water intake rose three-fold during EB administration and this was due to increases in both the duration and frequency of drinking bouts. The similarity in effects induced by EB on the patterns of food and ethanol intake were discussed in terms of ethanol's caloric property.
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