99% Altrenogest powder E-mail: firstname.lastname@example.org
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Product name: Altrenogest
CAS Registry Number: 850-52-2
Molecular Formula: C21H26O2
Molecular Weight: 310.43
Physical State: Solid
Storage: Store at room temperature
Appearance: Light yellow crystal or powder
Usage:A synthetic trienic C21 steroidal progestomimetic
Progesterone is produced predominantly from the corpus luteum. They will proliferative endometrium into secreted endometrium, enhance myometrial hypertrophy, inhibit spontaneous uterine contractions. Progesterone inhibits the secretion of pituitary gonadotropin in a dose-dependent manner, and also has a certain degree of estrogen, anabolism and androgen activity.
Altrenogest (or allyltrenbolone) is a synthetic triene C21 steroid hormone, belonging to the 19-tocopheryl ketone series. It is an oral active (pro) progesterone. Like all steroids, the altexine, by penetrating the target cells, is lipophilic in its binding to a specific receptor.
Altrenogest is indicated (labeled) to suppress estrus in mares to allow a more predictable occurrence of estrus following withdrawal of the drug.Clinically used to assist the mare in the transition from anesthesia to the normal breeding season is often accompanied by artificial light cycle to establish a normal cycle.
In the late transition period to more effectively assist pregnancy. A group of authors (Squires et al., 1983) suggested that maternal (mare, one or more follicular sizes of 20 mm or greater) with considerable follicular activity be selected for treatment in the transitional phase. Mares that have been estrus for more than 10 days and have active ovaries are also considered excellent candidates for progesterone therapy.
Altrenogest is effective in normal mare mares to minimize the need for estrus testing, for estrus synchronization and to allow regular breeding. Acans will be inoculated 2-5 days after treatment, and most sows will ovulate 8-15 days after evacuation. Altrenogest is also effective in suppressing estrus expression in sows or mares.
Although the drug was marked as contraindicated during pregnancy, it has been shown to remain pregnant in ovariectomized mares and may be discontinued due to sub-treatment of progesterone levels.
In veterinary medicine, altrenogest is used in gilts and mares for zootechnical purposes (oestrus synchronization). The recommended dose for gilts is 20 mg/animal/day given orally for 18 consecutive days, and for mares is 0.044 mg/kg bw/day given orally for 10 to 15 days.
Altrenogest Powder Adverse Effects/Warnings:
Adverse effects of altrenogest appear to be minimal when used at labeled dosages. One study (Shideler et al. 1983) found negligible changes in hematologic and most "standard" laboratory tests after administering altrenogest to 4 groups of horses (3 dosages, 1 control) over 86 days.
Occasionally, slight changes in Ca++, K+, alkaline phosphatase and AST were noted in the treatment group, but values were only slightly elevated and only noted sporadically. No pattern or definite changes could be attributed to altrenogest. No outward adverse effects were noted in the treatment group during the trial.
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