99% purity Anti Estrogen Pregnenolone Powder CAS145-13-1 Pharmaceutical Intermediate
Product name: Pregnenolone
Key words: Pregnenolone, Pregnenolone, Pregnenolone, Pregnenolone, estrogen hormone powder,
Pregnenolone, Pregnenolone, estrogen hormone powder
CAS No: 145-13-1
Molecular Formula: C21H32O2
Molecular Weight: 316.48
Quality Standard: Enterprise Standard
Packing: 1kg/foil bag
The MOQ: 10g
Appearance: White or almost white crystalline powder
Usage: White crystalline powder. Melting point 193. Insoluble in water. Use for biochemical studies. Progesterone hormone class medicine intermediate
What is Pregnenolone
Pregnenolone , also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.
Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.
Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to improve cognitive and memory functioning. Pregnenolone is also being considered as a potential treatment for schizophrenia.
Interestingly, unlike pregnenolone, pregnenolone sulfate is a negative allosteric modulator of the GABAA receptor as well as a positive allosteric modulator of the NMDA receptor. In addition, it has been shown to activate the transient receptor potential M3 (TRPM3) ion channel in hepatocytes and pancreatic islets causing calcium entry and subsequent insulin release.
Clinical studies have shown Pregnenolone to relieve symptoms of rheumatoid arthritis and osteoarthritis.
Another effect is to reduce levels of cortisol, especially when they have previously risen to an excessive concentration. It also helps to boost natural immunity, dramatically relieve fatigue, and restore energy levels.
Pregnenolone is also effective at helping to restore and balance out one's mood. Not only does it appear to promote a positive mental outlook, but it also alleviates a number of mood disorders, relieves symptoms of clinical depression, and even heals some of the pain associated with fibromyalgia.
The supplement alleviates chronic insomnia and other sleep disorders and helps with many symptoms of chronic degenerative diseases like diabetes, MS, and lupus. Pregnenolone is also reported to have benefits for those suffering from nervous conditions such as stress and anxiety.
White crystalline powder
Loss on drying
Conform to standard
Identical with and at least nearly equivalent to the pregnenolone reference standard with reference to integrity, intensity, spot color and RF value, compared to sample FR0025
Related substances (HPLC)
Any single impurity: ≤0.4 a/a%
Total impurities: ≤1.0 a/a%
Assay (dried basis)
The test result of the above mentioned product meets the enterprise standard
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