Toremifene Citrate Fareston Acapodene 89778-27-8 for Advanced (metastatic) Breast Cancer Treatment

Toremifene Citrate Fareston Acapodene 89778-27-8 for Advanced (metastatic) Breast Cancer Treatment

Quick Detail Product Description Introduction Citrate toremine (/ toʊrᵻmᵻfin /) is an oral selective estrogen receptor modulator (SERM) that helps fight estrogen in the body. Torremethin citrate was approved by the FDA for advanced (metastatic) breast cancer in the United States in the name of...

Product Details

Quick Detail

Product Name

Toremifene Citrate

CAS NO

89778-27-8

Assay

99% above

Molecular Weight

598.083

Density

1.045g/cm3

Boiling Point

535.1ºC at 760 mmHg

Molecular Formula

C32H36ClNO8

Melting Point

158-164ºC

Flash Point

277.4ºC

Appearance

White Powder

Packaging

1kg foil bag

Price

3823-5735USD/KG

MOQ

1kg

Sample

Availability

Origin China

China

Payment Term

TT/West Union/Money Gram/Bitcoin

Delivery Time

3-5 working days by express normally

Product Description

Introduction

Citrate toremine (/ toʊrᵻmᵻfin /) is an oral selective estrogen receptor modulator (SERM) that helps fight estrogen in the body. Torremethin citrate was approved by the FDA for advanced (metastatic) breast cancer in the United States in the name of Fareston. It is also being evaluated with brand name for Acapodene to prevent prostate cancer.

In 2007, the pharmaceutical company GTx was conducting two different Phase 3 clinical trials; first, for the treatment of advanced prostate cancer, androgen deprivation therapy (ADT) (especially vertebral / spine fractures and hot flushes, lipid profiles and men's breasts Development) of the critical phase of clinical trials, followed by the critical phase III clinical trial for the prevention of high grade prostate intraepithelial neoplasia of high risk male or prostate cancer in prostate cancer trials. The results of these trials are expected to begin in the first quarter of 2008

February 2009 submitted the first application (prostate cancer ADT side effects mitigation) of the NDA, in October 2009; the FDA said it would need more clinical data, such as another Phase III trial.

Structure

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Spectrum


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Applications

Fredium citrate (Fareston) is an anti-estrogen drug, SERM officially classified as non-steroidal tristyrenes derivatives. As anti-estrogen, Fareston acts by binding or attaching to estrogen receptors throughout the various tissues of the body, resulting in competition with estrogen. By ligating to different receptors, this prevents estrogen binding and performs its intended role. This is mainly because it prevents estrogen from binding to estrogen receptors in breast tissue.

Unlike the aromatase inhibitor (AI), a more potent antiestrogen type, Fareston does not have the ability to lower serum estrogen levels. The function of AI is to inhibit aromatization, that is, testosterone into estrogen; this in turn reduces the human serum estrogen levels; now estrogen can reduce the role of estrogen. However, when using Fareston, circulating estrogens do not have the ability to carry out breast cancer or a disease that is common to many male steroid users.

Among the different features of Fareston, the more interesting is its relationship with testosterone. Most SERMs have the ability to stimulate natural testosterone production, especially to enhance the release of luteal hormone (LH) and follicle stimulating hormone (FSH). For this reason, SERMs like Nolvadex and Clomid are commonly used for PCT purposes because of the inhibitory status of natural testosterone production after the use of synthetic metabolic steroids. This is why SERM is used as maternity assistance like Clomid, because the increase in gonadotropin can promote conception. However, different from these SERMs of Fareston has been shown to significantly increase sex hormone binding globulin (SHBG), which in turn leads to lower levels of free testosterone. This makes Fareston an unfavorable choice for the PCT, where the PCT is primarily concerned with elevated levels of testosterone.

The last explanation about Fareston's features and features revolves around cholesterol. Although anti-estrogen is essentially anti-estrogen. Fareston will actually serve as estrogen in the liver, which will support a healthier lipid spectrum. Because it acts as an estrogen in the liver, this will support lowering LDL cholesterol and synthesizing HDL cholesterol. In fact, while other SERMs carry this capability, Fareston has proven to be able to take it to the strongest level, making it an excellent choice for synthetic metabolic steroid users in the fight against men's breast development.

Adverse Effects

Fareston is a very well tolerated SERM. Fareston has the potential side effects, but they do not seem to be common, Fareston's most common side effects are not that we can mark serious ones. Fareston's most common side effects are hot flashes and excess sweat. About 35% of Fareston patients will experience hot flashes and 20% excess sweating. Other possible side effects of Fareston include:

Nausea

Elevated liver enzymes

Vaginal secretions

Edema (rare)

Vomiting (very rare)

Vaginal bleeding (rare)

Some Fareston users may also feel dizzy; in fact, this is actually very common in the early stages of use. Then we left the final side effects of Fareston, and they were surrounded by a popular debate. These are the more serious side effects that Fareston may have, but they also have some important precautions:

Low white blood cell count

Dermatitis

Dizziness

Loss of power

Hair loss

Depression

Jaundice

Constipation

Difficulty breathing

Visual harassment

Part of the movement paralysis

Some of these side effects of Fareston sound a lot of trouble, but they may also be almost unheard of. More importantly, patients with this symptom during use have not yet demonstrated that Fareston is causing this response because many patients also take other drugs and other factors in the event of these problems. Because it is such a new SERM, it may take years to study completely to point out the overall action. However, because of its strong cholesterol-friendly and good overall anti-estrogen and overall tolerability, it is still promising in the future.

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Our lab can customize the right product and support u with our top specialists. So if u have a recipe and need help just inform us. We can make experiments and get a good result.

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