Tamoxifen Nolvadex 10540-29-1 Breast Cancer Treatment

Tamoxifen Nolvadex 10540-29-1 Breast Cancer Treatment

Quick Detail Product Description Introduction Tamoxifen (TMX), marketed under the trade name Nolvadex, is a drug used to prevent breast cancer in women and treat women and male breast cancer and is also investigating other types of cancer. [3] It has been used for Albright syndrome. Tamoxifen is...

Product Details

Quick Detail

Product Name





99% above

Molecular Weight



1.0±0.1 g/cm3

Boiling Point

482.3±33.0 °C at 760 mmHg

Molecular Formula


Melting Point


Flash Point

140.0±27.7 °C


White Powder


1kg foil bag







Origin China


Payment Term

TT/West Union/Money Gram/Bitcoin

Delivery Time

3-5 working days by express normally

Product Description


Tamoxifen (TMX), marketed under the trade name Nolvadex, is a drug used to prevent breast cancer in women and treat women and male breast cancer and is also investigating other types of cancer. [3] It has been used for Albright syndrome. Tamoxifen  is usually daily breast cancer for 5 years.

Severe side effects include uterine cancer, stroke, vision problems and less risk of pulmonary embolism. Common side effects include irregularities, weight loss and hot flashes. If you take during pregnancy or breastfeeding, you may cause harm to your baby. [4] It is a selective estrogen receptor modulator (SERM) that acts by reducing the factors that increase the growth of mammary gland cells and increase the growth of mammary gland cells. It is a triphenylvinyl group

Tamoxifen was found in 1967. [7] In the World Health Organization's list of essential medicines, the most effective and safe drug Tamophoxine required for the health system can be used as a generic drug. The wholesale price for developing countries is $ 0.07 to $ 0.23 per day. In the United States, it costs about $ 2 a day.






Tamoxifen is currently used to treat early and late estrogen receptor (ER) positive (ER +) breast cancer in premenopausal and postmenopausal women. In addition, it is the most common hormone therapy for male breast cancer. It is also approved by the FDA for the prevention of breast cancer in women with high disease. Has been further approved to reduce contralateral (breast cancer). Thamoxifen is recommended for 10 years.

In 2006, large clinical trials of STAR concluded that raloxifene was equally effective in reducing the incidence of breast cancer, but an average of 4 years of follow-up, raloxifene women with 36% reduction in uterine cancer, blood clot reduction of 29% Among the women taking tamoxifen, the difference was not statistically significant.

Dosing Administration

Routine adult dose of breast cancer

Metastatic breast cancer for the treatment of women and men:

20 to 40 mg oral dose should be greater than 20 mg, divided doses (sooner or later).

For the treatment of in situ ductal cancer women, the following breast surgery and radiation:

20 mg orally daily for 5 years

Reduce the incidence of breast cancer in high-risk women with breast cancer:

20 mg orally daily for 5 years

Breast cancer routine adult dose - adjuvant

For mastectomy or segmental mastectomy, axillary resection and breast irradiation after postmenopausal women with lymph node-positive breast cancer treatment:

10 mg orally, 2 to 3 times a day for 5 years

Breast cancer routine adult dose - palliative treatment

10 to 20 mg orally twice daily

A few months after the start of treatment, the beneficial response may not be obvious.

Routine pediatric dose of McCune-Albright syndrome

For McCune-Albright syndrome and premature puberty 2 to 10 year old girl:

20 mg once a day Treatment time up to 12 months

The usual pediatric adolescent dose

For McCune-Albright syndrome and premature puberty 2 to 10 year old girl:

20 mg once a day Treatment time up to 12 months

Adverse Effects

September 2009 Health and Human Services A report by the Healthcare Research and Quality Department shows that tamoxifen, raloxifene and tibolone for breast cancer can significantly reduce middle- and older women's aggressive Breast cancer occurs, while also increasing the risk of adverse side effects

Because of the possible thrombosis and deep vein thrombosis (DVT) caused by the drug, some cases of lower limb lymphedema are associated with the use of tamoxifen. Blood clots or DVTs need to be resolved before starting lymphoid edema.


The beneficial side effect of tamoxifen is to prevent bone loss by acting as an ER agonist (i.e., mimetic estrogen) in the cell type. Therefore, by inhibiting osteoclasts, it can prevent osteoporosis. When tamoxifen was introduced as a drug, it was thought that tamoxifen could act as an ER antagonist in all tissues, including bones, and therefore feared that it would contribute to osteoporosis. Therefore, the clinical observation of the opposite effect is very surprising. Thus, the selective role of tamoxifen leads directly to the formation of the SERMs concept. In contrast, tamoxifen appears to be associated with bone loss in premenopausal women who continue to follow menstruation after chemotherapy.

Endometrial cancer

Tamoxifen is a SERM. Even if it is an antagonist in breast tissue, it acts as part of the endometrial agonist and is associated with endometrial cancer in some women. Thus, changes in endometrium, including cancer, are side effects of tamoxifen. Over time, the risk of endometrial cancer may be doubled to four times that of tamoxifen is usually only a five-year cause.

The American Cancer Society lists tamoxifen as a known carcinogen, suggesting that it can increase the risk of certain types of uterine cancer while reducing the risk of breast cancer recurrence. ACS pointed out that if the risk of breast cancer recurrence without drugs is higher than the risk of using the drug to develop uterine cancer, the drug should not be avoided.

Cardiovascular and metabolic

Tamoxifen treatment of postmenopausal women is with serum lipid profile. However, long-term data from clinical trials failed to demonstrate cardioprotective effects. For some women, tamoxifen may lead to a rapid increase in the concentration of triglycerides in the blood. In addition, the risk of thromboembolism is increased, especially during surgery and subsequent surgery or inactivity. Tamoxifen is also the cause of fatty liver, also known as cirrhotic liver disease or hepatic steatosis.

Central Nervous System

Tamoxifen treatment of breast cancer patients showed evidence of cognitive reduction, tamoxifen's primary side effects and semantic memory scores. However, patients treated with tamoxifen had less memory impairment compared with patients treated with anastrozole (aromatase inhibitors).

A large number of tamoxifen treatment of breast cancer patients experienced decreased libido.

Premature growth plate fusion

Although tamoxifen has been shown to antagonize the role of estrogen in tissues such as the mammary glands, its role in other tissues such as bones has not been adequately documented. Studies have been conducted in mice to show that tamoxifen mimic the effect of estrogen on bone metabolism and bone growth. This effect is no longer of concern in adults.

Our Service

1.Quality Product and Good Price

We offer absolute high quality product in customized or non-customized. If there are any problems in quality, please contact me as soon as possible.

2. Fast &Secure Shipping

Generally, for small quantity product, the product will be shipped by courier.

For bulk goods, usually you will receive the product within 15 working days.

The rate of passing customs is more than 90%.

3. Reshipping Policy

Even for the worst situation when the product is blocked by the customs, we can reship the product without any extra payment for the product.

4. Technical Supports

Our lab can customize the right product and support u with our top specialists. So if u have a recipe and need help just inform us. We can make experiments and get a good result.


1 What about the payment?Is it secure?

Payment can be TT, West Union, Money Gram and Bitcoin. As a well-known supplier, thousands of buyers pay as mentioned. It is warmly welcome to visit our company, discuss and deal face to face.

2 How can I ensure I get the right product?

Before placing an order, you first call us getting specific information like purity, quantity, usages, packing terms, stocking conditions etc. The more details you offer the better result you can have. When shipping, our service center will inform you with the tracking number, packing terms and quantity.

3 How to contact us directly?

Please feel free to contact me: