SR9011 CAS 1379686-29-9 for Muscling

SR9011 CAS 1379686-29-9 for Muscling

Quick Detail Product Description Introduction SR9011 is a research drug developed by Professor Thomas Burris of Scripps as an agonist of Rev-ErbAα, a semi-maximal inhibitory concentration of Rev-Erbα (IC50) = 790 nM, and IC50 of Rev-ErbAβ = 560 nM. SR 9011 is a REV-ERB agonist that increases the...

Product Details

Quick Detail

Product Name

SR9011

CAS NO

1379686-29-9

Assay

99% above

Molecular Weight

N/A

Density

N/A

Boiling Point

N/A

Molecular Formula

C23H31ClN4O3S

Melting Point

N/A

Flash Point

N/A

Appearance

White Powder

Packaging

1kg foil bag

Price

N/A

MOQ

1kg

Sample

Availability

Origin China

China

Payment Term

TT/West Union/Money Gram/Bitcoin

Delivery Time

3-5 working days by express normally

Product Description

Introduction

SR9011 is a research drug developed by Professor Thomas Burris of Scripps as an agonist of Rev-ErbAα, a semi-maximal inhibitory concentration of Rev-Erbα (IC50) = 790 nM, and IC50 of Rev-ErbAβ = 560 nM.

SR 9011 is a REV-ERB agonist that increases the constitutive inhibition of genes regulated by REV-ERB [alpha] and REV-ERB [beta], with IC50 values of 790 and 560 nM, respectively. Other nuclear receptors are not active. SR9011 blocked the activity of the optic chiasm (SCN) clock, reversing inhibition of circadian rhythmic oscillations from Per2-luc reported mouse-cultured SCN explants. The circadian rhythm patterns of several metabolic genes in the liver, skeletal muscle and adipose tissue also show changes in mice exposed to SR 9011, resulting in increased energy consumption.

SR9011 is an effective and specific synthetic REV-ERB agonist that binds REV-ERB-α of EC50 to 790 nM and REV-ERB-[beta] of EC50 to 560 nM. It also has good in vivo plasma / brain exposure. Nuclear receptors REV-ERB-α and REV-ERB-β plays an indispensable role in regulating the expression of core clock proteins, promoting rhythms in activity and metabolism. The administration of SR9011 changed the circadian rhythm patterns of circadian rhythm behavior and core clock gene expression in the hypothalamus of mice. Liver, skeletal muscle and adipose tissue in a series of metabolic genes circadian rhythm expression pattern also changed, resulting in increased energy consumption. Treatment of diet-induced obese mice with SR9011 reduces fat levels by reducing fat and significantly improves dyslipidemia and hyperglycemia. These results suggest that pharmacological targeting of circadian rhythms of synthetic REV-ERB ligands may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

Dosing Administration

In vitro: SR9011 was used in vitro and in cell assays at a concentration of 5-10 [mu] M.

In vivo: In different mouse models, IP administration of SR9011 was administered at a dose of 100 mg / kg once or twice daily for 12-30 days.

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