Finasteride Proscar Propecia 98319-26-7 for Enlarged Prostate and Androgenetic Alopecia

Finasteride Proscar Propecia 98319-26-7 for Enlarged Prostate and Androgenetic Alopecia

Quick Detail Product Description Introduction Finasteride is sold under the brand name Proscar and Propecia and is used to treat benign prostatic hyperplasia (prostate enlargement) and pattern hair loss. It is type II and III type 5α-reductase inhibitors; 5α reductase, enzyme, testosterone is...

Product Details

Quick Detail

Product Name

Finasteride

CAS NO

98319-26-7

Assay

99% above

Molecular Weight

372.544

Density

1.1±0.1 g/cm3

Boiling Point

576.6±50.0 °C at 760 mmHg

Molecular Formula

C23H36N2O2

Melting Point

253 °C

Flash Point

177.4±30.3 °C

Appearance

White Powder

Packaging

1kg foil bag

Price

3676-5514USD/KG

MOQ

1kg

Sample

Availability

Origin China

China

Payment Term

TT/West Union/Money Gram/Bitcoin

Delivery Time

3-5 working days by express normally


Product Description

Introduction

Finasteride is sold under the brand name Proscar and Propecia and is used to treat benign prostatic hyperplasia (prostate enlargement) and pattern hair loss. It is type II and III type 5α-reductase inhibitors; 5α reductase, enzyme, testosterone is converted to dihydrotestosterone (DHT).


Treatment of urethral problems caused by increased prostate (benign prostatic hyperplasia [BPH])). It is also used to reduce the risk of surgical treatment of BPH. It can be used with another drug (doxazosin) to reduce the risk of BPH deterioration. It can also be used for other conditions that your doctor has identified.


Finasteride is a steroid reductase inhibitor. It works by reducing the amount of dihydrotestosterone (DHT) in the body. This makes the prostate smaller, which helps to relieve urine problems.


Structure

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Spectrum


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Applications

Prostate enlargement

Doctors sometimes use finasteride to treat BPH, informally known as the enlarged prostate. Finasteride can improve symptoms associated with BPH, such as dysuria, get up at night, urination; urination began to hesitate, reduced urinary flow. It provides less symptom relief than alpha-1 blockers such as tamsulosin, and slows the onset of symptoms (it may take 6 months or more to treat finasteride to determine the outcome). Prostate volume ≥ 40cm3 patients are mainly seen in the symptoms. Long-term studies of finasteride but not alpha-1 inhibitors reduced the risk of acute urinary retention (-57% at 4 years) and surgery required (54% at 4 years). If the drug is discontinued, any treatment effect can be reversed in about 6-8 months.


Hair loss pattern

Finasteride is sometimes used only for the treatment of male hair loss (androgenic hair loss). The treatment slows down further hair loss and provides about 30% improvement in hair loss after 6 months of treatment, and its efficacy is usually sustained as long as the medication is administered, although hair loss is reduced indefinitely after hair loss. Finasteride has also been tested for women's pattern hair loss; the results are no better than placebo.


Non-tagged use

Hair grows too fast

It has been found that finasteride can effectively treat women's hirsutism (excessive facial and / or body hair growth). [11] In the study of 89 women with orrogenic hyperactivity caused by persistent adrenal cortical syndrome, finasteride had a 93% reduction in facial hirsutism after 2 years of treatment and reduced body hirsutism 73%. Other studies using finasteride for hirsutism have also found that it is clearly effective.


Transgender women

Finasteride is sometimes used in hormone replacement therapy for transsexuality in combination with estrogen forms because of its antiandrogenic properties. However, there have been few studies of finasteride for this purpose, and evidence of efficacy is limited. In addition, when finasteride can be associated with side effects such as depression, anxiety and suicidal ideation, it is advisable to prescribe finasteride, particularly in transsexuals and other high risk risks.


Dosing Administration

Finasteride can provide additional patient leaflets. If you have any questions about this information, please contact your pharmacist.

With or without food taking finasteride

Even if you feel good, continue to take finasteride. Do not miss any dose.

Taking finasteride at the same time every day can help you remember taking.

If you miss the dose of finasteride, skip the missed dose and return to your routine dosing regimen. Do not take 2 doses at a time.

Ask your health care provider about how to use finasteride.


Adverse Effects

2010 Cochrane assessment concluded that the side effects of finasteride were low when used in BPH. Compared with placebo, men taking finasteride were at increased risk of eosinopathy, erectile dysfunction, decreased libido and ejaculation in the first year of treatment. In this review, the proportion of these effects was incompatible with placebo after 2-4 years, and these side effects usually improved over time. Another 2010 review found that when used for hair loss of finasteride, the incidence of sexual problems increased. A review of benign prostatic hyperplasia of 5α-reductase inhibitors in 2016 found that sexual dysfunction was 2.5 times greater in people who used them.


In men with benign prostatic hyperplasia, the use of 5α-reductase inhibitors and α1-adrenergic receptor blockers results in greater risk of erectile dysfunction as compared to the use of either drug alone.


Because treatment of BPH reduces PSA (prostate specific antigen), the FDA may warn of 5α-reductase inhibitors to increase the risk of advanced prostate cancer, which may mask the development of prostate cancer. Although the overall incidence of male breast cancer has not increased in the 5 mg clinical trial of finasteride, there is still a listing report associated with the use of breast cancer. The evidence does not indicate whether there is a causal relationship between finasteride and these cancers.


The meta-analysis in 2015 found that clinical trials of detection of finasteride in hair loss did not have adequate safety reporting and did not provide sufficient information to determine the safety of finasteride as a hair loss treatment. The study concluded that the clinical trials of finasteride alopeca provide very limited toxicity information, poor quality, and appear to be systematically biased towards inadequate detection of adverse events. In addition, trials submitted to the FDA for approval of hair loss exclude most men who are commonly used for finasteride treatment of androgenic hair loss.


Although it is considered a cosmetic problem, and not necessarily a detrimental effect, male breast development may also occur after the use of finasteride, which may be the source of psychological distress.


Sexual dysfunction

Whether finasteride causes long-term dysfunction in men after discontinuation is unclear. There are some cases reported that the drug has been discontinued after persistent sexual desire to reduce or erectile dysfunction, FDA has updated the label to inform people of these reports. The 2010 review found moderate quality evidence that finasteride increased the risk of sexual dysfunction, but not because of sexual side effects that stopped using it.


When finasteride was originally approved for hair loss in 1997, the FDA approved a review report showing that it appears to be well tolerated and that the most common side effects are related to sexual function. In many people, if the drug stops, even if the medication continues to solve these side effects occasionally. They also pointed out that "sexual function questionnaires seem to give a sensitive reflection of sexual intercourse."


Meta-analysis and systematic assessment found that sexual dysfunction (including erectile dysfunction, libido and semen reduction) in men with finasteride or dutasteride treatment may occur between 3.4 and 15.8%. This is related to a decline in the quality of life that may lead to stress. There is also a link to reduce libido. It is reported that in a small part of men, these adverse side effects may persist even after the use of finasteride or dutasteride.


2010 Cochrane assessment concluded that the side effects of finasteride were low when used in BPH. Compared with placebo, men taking finasteride were at increased risk of eosinopathy, erectile dysfunction, decreased libido and ejaculation in the first year of treatment. In this review, the proportion of these effects was incompatible with placebo after 2-4 years, and these side effects usually improved over time. Another 2010 review found that when used for hair loss of finasteride, the incidence of sexual problems increased. A review of benign prostatic hyperplasia of 5α-reductase inhibitors in 2016 found that sexual dysfunction was 2.5 times greater in people who used them.


In men with benign prostatic hyperplasia, the use of 5α-reductase inhibitors and α1-adrenergic receptor blockers results in greater risk of erectile dysfunction as compared to the use of either drug alone.


Because treatment of BPH reduces PSA (prostate specific antigen), the FDA may warn of 5α-reductase inhibitors to increase the risk of advanced prostate cancer, which may mask the development of prostate cancer. Although the overall incidence of male breast cancer has not increased in the 5 mg clinical trial of finasteride, there is still a listing report associated with the use of breast cancer. The evidence does not indicate whether there is a causal relationship between finasteride and these cancers.


The meta-analysis in 2015 found that clinical trials of detection of finasteride in hair loss did not have adequate safety reporting and did not provide sufficient information to determine the safety of finasteride as a hair loss treatment. The study concluded that the clinical trials of finasteride alopeca provide very limited toxicity information, poor quality, and appear to be systematically biased towards inadequate detection of adverse events. In addition, trials submitted to the FDA for approval of hair loss exclude most men who are commonly used for finasteride treatment of androgenic hair loss.


Although it is considered a cosmetic problem, and not necessarily a detrimental effect, male breast development may also occur after the use of finasteride, which may be the source of psychological distress.


Sexual dysfunction

Whether finasteride causes long-term dysfunction in men after discontinuation is unclear. There are some cases reported that the drug has been discontinued after persistent sexual desire to reduce or erectile dysfunction, FDA has updated the label to inform people of these reports. The 2010 review found moderate quality evidence that finasteride increased the risk of sexual dysfunction, but not because of sexual side effects that stopped using it.


When finasteride was originally approved for hair loss in 1997, the FDA approved a review report showing that it appears to be well tolerated and that the most common side effects are related to sexual function. In many people, if the drug stops, even if the medication continues to solve these side effects occasionally. They also pointed out that "sexual function questionnaires seem to give a sensitive reflection of sexual intercourse."


Meta-analysis and systematic assessment found that sexual dysfunction (including erectile dysfunction, libido and semen reduction) in men with finasteride or dutasteride treatment may occur between 3.4 and 15.8%. This is related to a decline in the quality of life that may lead to stress. There is also a link to reduce libido. It is reported that in a small part of men, these adverse side effects may persist even after the use of finasteride or dutasteride.


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