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To the brand name Avodart and other sales of dutasteride is used to treat benign prostatic hyperplasia (prostate enlargement) and androgenic hair loss (pattern hair loss) drugs.
It is developed by GlaxoSmithKline and is a 5α-reductase inhibitor that prevents the androgenic testosterone from converting to more effective dihydrotestosterone (DHT). The drug has been licensed for the treatment of androgenic hair loss since 2009, but has not yet been recognized by the specific indications in the United States, although it is commonly used for labeling agents.
It is used as the Treatment of benign prostatic hyperplasia (BPH) or prostate enlargement symptoms. It also helps to reduce the risk of urinary obstruction and the need for surgical treatment of BPH. It can be used alone or in combination with another drug (tamsulosin).
Dutasteride is a 5α-reductase inhibitor. It works by reducing the level of hormones called DHT (DHT), which is the leading cause of prostate growth. Reduced DHT leads to increased prostate contraction.
Additional patient leaflets are available for diamine. If you have any questions about this information, please contact your pharmacist.
With or without food taking tamadolin
Do not break, crush, chew or open. Do not use capsules that break, deform, discolor or leak. Dutasteride can stimulate your lips, mouth and throat.
Regular administration of tamadain to maximize the benefits
Daily administration of dutasteride can help you remember taking
Even if you feel good, continue to take dutasteride. Do not miss any dose.
If you miss a dose of dutasteride, if you remember the day as soon as possible
If you do not remember until the next day, skip the missed dose. Do not take 2 doses at a time.
Does your health care provider have any questions about how to use dutasteride.
In general, dutasteride is well tolerated in male and female studies with little side effects. The important potential side effects of ditrolactam in a small number of patients may include sexual dysfunction and depression. Other general side effects include headache and gastrointestinal discomfort. Changes in menstruation, acne and dizziness are also reported. Male breast development (breast enlargement) risk is very small. In pregnant women, dutasteride can cause male birth defects, that is, genital blurred, and therefore should not be given to them.
In men treated with finasteride or dutasteride, sexual dysfunction may occur, including erectile dysfunction, loss of libido and semen reduction. This is related to a decline in the quality of life that may lead to stress. There is also a link to reduce libido. It is reported that in a small part of men, these adverse side effects may persist even after the use of finasteride or dutasteride.
Depression and self-harm
Several small studies have reported the association between 5α-reductase inhibitors and depression. However, most of the studies did not observe this side effect. Even after the discontinuation of dutasteride, there are some long-term persistent depression in the male part of the report still exists.
Recently, a very large population-based matched cohort study found that finasteride and dutasteride were significantly associated with a significant increase in the risk of depression in 93,197 males aged 66 and older (HR = 1.94; 95% CI 1.73- (HR, 0.88; 95% CI, 0.53-1.45) before suicide (HR, 1.88; 95% CI, 1.34-2.64) before 18 months of treatment, but did not increase the risk of suicide After the first 18 months of treatment, the risk of self-injury was no longer increased, while the risk of depression increased slightly (HR, 1.22; 95% CI, 1.08-1.37). The absolute incidence of depression is 247 cases per 100,000 patients, 17 cases of their own injuries, every 100,000 cases of patients. Thus, on the basis of these statistics, it has been pointed out that cases of depression in patients who are due to 5α-reductase inhibitors are sometimes encountered, and cases of self-harm attributable to 5α-reductase inhibitors are encountered Very few There was no statistically significant difference in depression, self-injury and suicide rates between finasteride and dutasteride, indicating that the type of 5α-reductase inhibitor did not affect the risk.
The US Food and Drug Administration have added a warning to the increased risk of elevated levels of tamoxifen in prostate cancer. Although the potential for positive, negative or neutral changes to the potential risk of developing prostate cancer has not yet been determined, evidence suggests that it may temporarily reduce the growth and prevalence of benign prostate tumors, but also cover early detection of prostate cancer. The main concern is the possible development of patients with prostate cancer, while taking ditrolactam for benign prostatic hyperplasia, which in turn may delay the diagnosis and early treatment of prostate cancer, potentially increasing the risk of developing advanced prostate cancer in these patients.
Children who are or are likely to be pregnant and who have significant hypersensitivity (eg, severe skin reactions, angioedema) do not take dutasteride. In contact with tamadolin and other 5α-reductase inhibitors during pregnancy can cause birth defects. Because these drugs are easily absorbed through the skin, so pregnant women should not be handled, if exposed to the leakage of the capsule, the contact area should be immediately washed with soap and water. The person who is taking his male should not donate blood, because of its long half-life, at least 6 months after the treatment stopped bleeding.
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