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Pentapixine, the Priligy and Westoxetin, and other brand marketing, is the first compound developed for the treatment of premature ejaculation (PE) for men aged 18-64 years. Dapoxetine increases the effect of serotonin in 5-synaptic fissures by inhibiting serotonin transporter, thereby promoting ejaculation delay. As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was originally produced as an antidepressant. However, unlike other SSRIs, dapoxetine is rapidly absorbed and eliminated in the body. Its rapid effects make it suitable for PE treatment, but not for antidepressants.
Originally created by Eli Lilly Pharmaceuticals, Dapositine was sold to Johnson & Johnson in 2003 and filed in 2004 as a new drug application to the Food and Drug Administration (FDA) for PE. Dapoxetine is sold in several European and Asian countries in Mexico. In the United States, dapoxetine has been in the third phase since 2003. But it is expected to be available soon. In 2012, Menarini was given the right to commercialize dapoxetine in most parts of Europe, Asia, Africa, Latin America and the Middle East.
Randomized, double-blind, placebo-controlled trials have confirmed the efficacy of dapoxetine in the treatment of PE. Different doses have different effects on different types of PEs. Dapoxetine 60 mg significantly improved the average vaginal ejaculation time (IELT) for men with lifetime PE, while dortezine 30 mg, while men had no significant difference in follow-up. Dapoxetine, which prolonged IELT 1-3 hours before sexual episode, increased the sense of control and sexual satisfaction of men aged 18 to 64 years. Because PE is associated with personal distress and is difficult to interrelated, daptachine can help men to overcome this situation. Other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine and citalopram have been used as a drug for the treatment of PE because of the lack of specific approval for PE in the United States and other countries. Meta-analysis by Waldinger showed that the use of these conventional antidepressants increased IELT from two to nine times the baseline to three to eight times that of dapoxetine. [However, these SSRIs must be taken daily to achieve a meaningful effect, long-term half-life will increase the risk of drug accumulation, thereby increasing adverse reactions, such as decreased libido, causing erectile dysfunction. On the other hand, daucoxetine is a fast acting SSRI. It is quickly absorbed and removed from the body in hours. This beneficial pharmacokinetics minimizes the risk of drug accumulation in the body, thereby reducing side effects.
The most common effect of taking docetaxine is nausea, dizziness, dry mouth, headache, diarrhea and insomnia. Suspension is due to adverse effects. According to McMahon's recent study in Asia, the discontinuation rates were 1067, with placebo, daroxetine 30 mg and daucoxetine 60 mg subjects were 0.3%, 1.7% and 5.3%, respectively. Unlike other SSRIs that are different from other patients with a high incidence of treatment dysfunction, dapoxetine is associated with low functional dysfunction. Dapoxetine has a very mild adverse effect on libido (<1%) and ED (<4%) as needed.
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