Cialis Tadalafil Adcirca 171596-29-5 for Erectile Dysfunction ED Treatment

Cialis Tadalafil Adcirca 171596-29-5 for Erectile Dysfunction ED Treatment

Quick Detail Product Description Introduction (INN) [2] is a PDE5 inhibitor in the form of pills for the treatment of erectile dysfunction (ED) under the name Cialis / siælᵻs / see-AL-iss, under the name Adcirca / ædsɜːrkə / ad- SUR-kə for the treatment of pulmonary hypertension. In October...

Product Details

Quick Detail

Product Name

Tadalafil

CAS NO

171596-29-5

Assay

99% above

Molecular Weight

389.404

Density

1.5±0.1 g/cm3

Boiling Point

679.1±55.0 °C at 760 mmHg

Molecular Formula

C22H19N3O4

Melting Point

298-300ºC

Flash Point

364.5±31.5 °C

Appearance

White Powder

Packaging

1kg foil bag

Price

588-882USD/KG

MOQ

1kg

Sample

Availability

Origin China

China

Payment Term

TT/West Union/Money Gram/Bitcoin

Delivery Time

3-5 working days by express normally


Product Description

Introduction

(INN) [2] is a PDE5 inhibitor in the form of pills for the treatment of erectile dysfunction (ED) under the name Cialis / siælᵻs / see-AL-iss, under the name Adcirca / ædsɜːrkə / ad- SUR-kə for the treatment of pulmonary hypertension. In October 2011, the US Food and Drug Administration (FDA) approved the signs and symptoms of Cialis for benign prostatic hyperplasia (BPH), and a combination of BPH and erectile dysfunction when conditions were met. It was originally developed by Biotech ICOS and was re-developed and marketed by ICOS and Lilly ICOS LLC, a joint venture between Eli Lilly. Cialis tablets at a dose of 2.5 mg, 5 mg, 10 mg and 20 mg were yellow, film coated and almond. The dose of pulmonary hypertension was 40 mg once daily (20 mg tablets).


He is also manufactured and sold by the Indian pharmaceutical company Cipla at a dose of 10 mg and 20 mg under the name Tadacip.


On November 21, 2003, the FDA approved the sale of tadalafil (as Cialis) in the United States as a third ED prescription pill (after Viagra and Levitra). Like sildenafil and vardenafil, talafil is recommended as a "essential" drug. Cialis is the only one that is once a day.


In addition, he was approved in the United States in May 2009 for the treatment of pulmonary hypertension [3] and conducted regulatory review in other areas. In late November 2008, Eli Lilly Corporation sold US pulmonary hypertension to its joint treatment company, prepaid $ 150 million.


Introduction

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Structure


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DosingAdministration

Conventional adult medication erectile dysfunction


Use ED as needed

- Initial dose: 10 mg per day before sexual activity as needed

- Dose: Doses 5 to 20 mg per day before sexual activity based on individual efficacy and tolerability


Comment: Considering that this drug has proven to be able to improve erectile dysfunction up to 36 hours after use as needed.


Use ED once a day

- Initial dose: 2.5mg orally, about the same time once a day, regardless of the time of sexual activity

Maintenance dose: 2.5 to 5 mg per day, depending on individual efficacy and tolerability.

Once daily for ED and benign prostatic hyperplasia (BPH):

About the same time once a day oral -5mg, regardless of sexual activity time

Purposes: treatment of erectile dysfunction (ED)


Routine adults for pulmonary hypertension

Adcirca (R)

Oral once every day -40mg

Comment: It is not recommended to divide the dose by 40 mg in one day.


Conventional adult dose for benign prostatic hyperplasia:

Daily use of BPH

Approximately 5 mg of oral administration at about the same time each day


Finasteride combined administration

-5 mg, about once a day for up to 26 weeks


Comment: The incremental benefit of this drug is reduced from 4 weeks to 26 weeks. The incremental benefit of this drug over 26 weeks is unknown.


Daily for ED and BPH

About the same time once a day oral -5mg, regardless of sexual activity time


Uses: treatment of benign prostatic hyperplasia (BPH) signs and symptoms


Adverse Effects

He has been used to participate in clinical trials of about 15,000 men, the world has more than 8 million men (mainly after approval / listing). The most common side effects of tadalafil are headaches, stomach discomfort or pain, indigestion, hiccups, acid reflux, back pain, muscle soreness, flushing, sulking or runny nose. These side effects reflect the ability of PDE5 to inhibit vasodilatation (leading to vasodilatation) and usually disappear after a few hours. After taking the drug 12 to 24 hours can occur back pain and muscle pain, symptoms usually disappear after 48 hours.


In May 2005, the US Food and Drug Administration found that statins (and other PDE5 inhibitors) were associated with some patients who had taken these drugs (NAA) (non-arterial anterior ischemic optic neuropathy) Visual impairment related to clinical trials). Most of these patients (but not all) suffer from anatomical or vascular risk factors associated with PDE5-independent NAION development, including: low cup versus plate ("crowded"), over 50 years of age, diabetes, hypertension, coronary Disease, hyperlipidemia and smoking. Because PDE5 uses fewer (less than one millionth of the NAION events), PDE5 inhibitors (millions) of large numbers of users, and events similar to those who do not take these drugs, the FDA believes that, given these patients' potential blood vessels Risk factors or anatomical defects, they can not draw causal relationships. However, the labeling of all three PDE5 inhibitors was altered to alert the clinician of possible association.


In October 2007, the FDA announced that the potential risk of sudden hearing loss was more pronounced for all PDE5 inhibitors, including tadalafil, due to deafness reporting associated with the use of PDE5 inhibitors.


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