Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
COA:
Product name
Procaine Hydrochloride
CAS No.
51-05-8
Outer Packing
25KG/drum
Production date
2017.08.25
Shelf life
2020.08.24
Standard adopted
USP37
Items of analysis
Specification
Results
Description
A white crystalline powder or colourless crystals
Complies
Identification
IR Absorption/Reaction of chlorides /Reaction of primary aromatic amines
Complies
Melting point
153-158℃
156.2-157.6℃
Color and clarity of solution
Colorless and clear
Conforms
Heavy metals
≤0.002%
<0.002%
pH (Acidity)
5.0~6.5 (≤0.02NNaOH0.5ml)
5.5/0.2ml
Chromatographic purity
≤0.05%(Sum≤1.0%)
Conforms
Loss on drying
≤0.5%
0.16%
Sulphated ash
≤0.1%
0.05%
Assay(C 13 H 20 N 2 O 2 .HCl)
99.0~101.0%
99.8%
Bacterial endotoxins
≤0.6EU/mg
<0.6EU/mg
Conclusion
Qualified
Dosage and Usage:
For infiltration anesthesia, the concentration of the solution is 0.25% to 0.5%, each time is 0.05 ~ 0.25g, and it can not exceed 1.5g per hour. It is not suitable for 1 times to exceed 0.15g and 5% solution. Local intravenous anesthesia was used in the extremities, and 0.5% solution was 40 ~ 150ml. The nerve conduction block used 1% to 2% solution, 1 times no more than 1G.
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