What is Procaine Hydrochloride?
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
COA:
Product name | Procaine Hydrochloride | ||
CAS No. | 51-05-8 | Outer Packing | 25KG/drum |
Production date | 2017.08.25 | Shelf life | 2020.08.24 |
Standard adopted | USP37 | ||
Items of analysis | Specification | Results | |
Description | A white crystalline powder or colourless crystals | Complies | |
Identification | IR Absorption/Reaction of chlorides /Reaction of primary aromatic amines | Complies | |
Melting point | 153-158℃ | 156.2-157.6℃ | |
Color and clarity of solution | Colorless and clear | Conforms | |
Heavy metals | ≤0.002% | <0.002% | |
pH (Acidity) | 5.0~6.5 (≤0.02NNaOH0.5ml) | 5.5/0.2ml | |
Chromatographic purity | ≤0.05%(Sum≤1.0%) | Conforms | |
Loss on drying | ≤0.5% | 0.16% | |
Sulphated ash | ≤0.1% | 0.05% | |
Assay(C 13 H 20 N 2 O 2 .HCl) | 99.0~101.0% | 99.8% | |
Bacterial endotoxins | ≤0.6EU/mg | <0.6EU/mg | |
Conclusion | Qualified | ||
Dosage and Usage:
For infiltration anesthesia, the concentration of the solution is 0.25% to 0.5%, each time is 0.05 ~ 0.25g, and it can not exceed 1.5g per hour. It is not suitable for 1 times to exceed 0.15g and 5% solution. Local intravenous anesthesia was used in the extremities, and 0.5% solution was 40 ~ 150ml. The nerve conduction block used 1% to 2% solution, 1 times no more than 1G.
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