What is Procaine Hydrochloride?
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
Items of analysis
A white crystalline powder or colourless crystals
IR Absorption/Reaction of chlorides /Reaction of primary aromatic amines
Color and clarity of solution
Colorless and clear
Loss on drying
Assay(C 13 H 20 N 2 O 2 .HCl)
Dosage and Usage:
For infiltration anesthesia, the concentration of the solution is 0.25% to 0.5%, each time is 0.05 ~ 0.25g, and it can not exceed 1.5g per hour. It is not suitable for 1 times to exceed 0.15g and 5% solution. Local intravenous anesthesia was used in the extremities, and 0.5% solution was 40 ~ 150ml. The nerve conduction block used 1% to 2% solution, 1 times no more than 1G.
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