Prilocaine hcl is a local anesthetic of the amino amide type. It is often used in dentistry. And it is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia.
Adult: Maxillary infiltration: initially 1–2mL; max recommended dose within a 2-hour period: <70kg: 8mg/kg; ≥70kg: 600mg. Elderly, debilitated, acutely ill: reduce dose.
Children: <10yrs: use Clarks rule to calculate dose.
Injection Onset :
When used for infiltration injection in dental patients, the time of onset of anesthesia averages less than 2 minutes with an average duration of soft tissue anesthesia of approximately 2 hours.
Possible Side Effect:
Swelling and persistent paresthesia of lips, oral tissue; CNS effects (eg, excitation, depression, restlessness, anxiety, dizziness, tremors), cardiovascular effects (eg, bradycardia, hypotension, cardiovascular collapse), allergic-type reactions, neurologic effects, increased creatinine phosphokinase.
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