99.5% Purity Glucocorticoid Hormone Powder Deflazacort CAS 14484-47-0

99.5% Purity Glucocorticoid Hormone Powder Deflazacort CAS 14484-47-0

Product description: Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort. Its potency is around 70-90% that of prednisone. It is sold in the United Kingdom...

Product Details

Quick details


Product name
DEFLAZACORT Factory Supplying
Other nameDEFLAZACORT INTERMEDIATE; Deflazacort;21-Deacetoxy Deflazacort
CAS register number14484-47-0
EINECS238-483-7
Molecular formulaC25H31NO6
Molecular weight441.52
Molecular structure
Melting point255-256.5°C
Assay98%

QQ截图20171214171135.jpg

Description
Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort. Its potency is around 70-90% that of prednisone.
It is sold in the United Kingdom by Shire under the trade name Calcort; in Brazil as Cortax, Decortil, and Deflanil; in India as MOAID, DFZ, Decotaz, and DefZot; in Panama as Zamen, Spain as Zamene and in Honduras as Flezacor. It is not available in the United States.


Introduction of compounds
Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort. Its potency is around 70-90% that of prednisone.
It is sold in Bangladesh as Xalcort, marketed by Beacon Pharmaceuticals Limited, in the United Kingdom by Shire under the trade name Calcort; in Brazil as Cortax, Decortil, and Deflanil; in India as MOAID, ZENFLAV BY TIGRIS, Defolet(Roussette), DFZ, Decotaz, and DefZot; in Panama as Zamen, Spain as Zamene and in Honduras as Flezacor. It is not available in the United States. In January 2015, the FDA granted fast track status to Marathon Pharmaceuticals to pursue approval of deflazacort as a potential treatment for Duchenne muscular dystrophy. The company expects to make deflazacort available in the United States in 2016.


Usage
The third generation of glucocorticoid, anti-inflammatory, anti-allergic, increase glycogen dysplasia, and so on. Used in primary and secondary adrenocortical hypofunction, rheumatism, collagen diseases, skin diseases, allergic disease, eye disease, explosive and disseminated tuberculosis, hematopoietic system disease, ulcerative colitis, idiopathic nephrotic syndrome, hematopoietic system malignant tumor, etc.


Certificate of Analysis

Items

Standard

Results

Description

White crystalline powder

white crystalline powder

Identification(IR,UV,HPLC)

Complies with the standard

complies

Solubility test

Freely soluble in acetic acid, methylene chloride, slightly

soluble in ethanol, acetone,

methanol, insoluble in water

complies

Melting point

255~258°C

255.0~256.0°C

Loss on drying

no more than 0.5%

0.05%

Water

no more than 0.5%

0.18%

Specific rotation

+58°~+62°

+61.2°

Heavy metals

no more than 10 ppm

complies

Sulphated ash

no more than 0.1%

0.05%

Individual impurity

no more than 1.0%

0.53%

Total impurities

no more than 2.0%

1.1%

Assay

97.0%~102.0%

99.7%

Residual solvents

Methanol NMT 300 ppm

complies

Dichioromethane NMT 600 ppm

complies

Ethyl acetate NMT 500ppm

complies

HTB1OOSbJpXXXXaiXXXX760XFXXXB.png


QQ截图20171215170328.jpg


other products

Anti-inflammatory
HP5001Colistin Sulfate1264-72-8
HP5002Gentamycin sulphate1405-41-0
HP5003Polymyxin B sulfate1405-20-5
HP5004Rifampicin13292-46-1
HP5005Rifaximin80621-81-4
HP5006Streptomycin Sulfate3810-74-0
HP5007Tacrolimus104987-11-3
HP5008Teicoplanin61036-62-2
HP5009Tobramycin sulfate79645-27-5
HP5010Vancomycin1404-90-6
HP5011Micafungin Sodium208538-73-2
HP5012Caspofungin Acetate179463-17-3
HP5013Loxoprofen sodium80382-23-6
HP5014Rapamycin53123-88-9


Please feel free to contact me:
Contact:claire
E-mail:claire@chembj.com
Skype:live:695059711
Whatapp:+8618123714275

Inquiry